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192 Monoclonal antibody anti-human CD36 (Platelet GPIV, Thrombospondin receptor) 1 ml
Part Number 192
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Description

Monoclonal antibody anti-human CD36 (Platelet GPIV, Thrombospondin receptor) (clone VM58, IgG1 kappa fraction)

Specificity

The monoclonal antibody is directed against the CD36 antigen (GP IV, GP IIIa, Thrombospondin receptor) (90 kDa), which is expressed on human platelets. Antibody reacts with platelets, monocytes, macrophages, erythroblasts and weakly with B-cells. In immunohistology the antibody reacts with some endothelial cells, adypocytes and the granular layer of the skin. Antibody induces Fc-receptor-dependent platelet aggregation after binding to platelet. The heterogeneity of the response found in healthy individuals is dependent on the polymorphism of the Fc RII on platelets

Preparation

Ammonium sulphate precipitation and DEAE-cellulose chromatography with gradient elution

Format

Purified and lyophilized from PBS with sodium azide. The azide concentration in reconstituted solution is 3 mM

Applications

Functional studies. Indirect immunofluorescence. Innumohistochemistry.

For fluorescence technique on cells fixation with 1% paraformaldehyde for 5 minutes is advised. Use for WB is not recommended

Reconstitution

Use 1 ml sterile pure water

Storage

Shipping at ambient temperature. Storage of lyophilized antibodies 2 years at -20C or lower

References

Gardiner EE, Karunakaran D, Arthur JF, Mu FT, Powell MS, Baker RI, Hogarth PM, Kahn ML, Andrews RK, Berndt MC. (2008) Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing FcgammaRIIa. Blood. 111(1):165-174

Burgess JK, Lindeman R, Chesterman CN, Chong BH. (1995) Single amino acid mutation of Fc gamma receptor is associated with the development of heparin-induced thrombocytopenia. Br J Haematol. 91(3):761-766

Mazurov AV, Vinogradov DV, Vlasik TN, Burns GF, Berndt MC. (1992) Heterogeneity of Platelet Fc-receptor-dependent Response to Activating Monoclonal Antibodies. Platelets. 3(4):181-188

Vinogradov DV, Vlasik TN, Agafonova OG, Vasil'ev SA, Lagutina NIa, Makarov VA, Berndt M, Mazurov AV. (1991) [Inhibition of Fc-receptor dependent platelet aggregation by monoclonal antibodies against the glycoprotein IIb-IIIa complex]. Biokhimiia. 56(5):787-797

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