Mouse monoclonal antibody against human urokinase-type plasminogen activator (uPA / PLAU; abbokinase), clone PGM2001, 1 mL. The epitope-distinct second mouse mAb in YO’s uPA antibody family — pair with cat. 335 (clone PGM2005) for mouse-mAb / mouse-mAb sandwich-ELISA on the same antigen, or with the neutralising polyclonal cat. 168 for capture / detect configurations. For uPA ELISA, IHC, Western blot and immunoprecipitation.
SPECIFICATIONS
Catalogue number: 381 | Host: Mouse | Target: Human
Target antigen: Urokinase-type plasminogen activator (uPA / PLAU; abbokinase)
Gene: PLAU (10q24.33) | UniProt: P00749
Clonality: Monoclonal | Clone: PGM2001 | Conjugate: Unconjugated
Specificity: Human uPA; epitope-distinct from clone PGM2005 (cat. 335), enabling two-mAb sandwich assays.
Format: Standard YO formulation | Package size: 1 mL
STORAGE / RECONSTITUTION
Reconstitute and handle per the supplied protocol. Ships at ambient temperature. Store lyophilised antibody 2 years at -20 °C or lower; store reconstituted antibody at +4 °C up to 4 weeks, or aliquot and freeze at -20 °C. Avoid repeated freeze-thaw.
APPLICATIONS
- ELISA — sandwich-ELISA capture or detection; pair with cat. 335 (sister mAb PGM2005, epitope-distinct) or the polyclonal cat. 168.
- IHC — uPA detection in tumour invasive fronts (uPA / PAI-1 biomarker), atherosclerotic plaque and glomerular disease.
- Western blot — detection of uPA forms.
- Immunoprecipitation — couple to Protein G beads.
APPLICATION HIGHLIGHTS — HIGH-VALUE RESEARCH NICHES
- Two-mAb sandwich ELISA (epitope-distinct mAb / mAb format) — high specificity for in-vitro-diagnostic uPA assays.
- Breast-cancer uPA / PAI-1 score biomarker IHC.
- Cancer-invasion research.
- Fibrinolysis and thrombosis research.
- Glomerulonephritis and atherosclerotic-plaque IHC.
